与2,5-二甲基-2,5-双-(过氧化叔丁基)己烷相关的文献报道

相关文献：

• 协和医科大学2006年硕士招生专业目录

  共1人,只招推免生(专业)1中国协和医科大学(005)基础医学院(083100)生物医学工程(02)生物医学信息处理与分析张正国共2人,含直博1人(专业)2(101)政治(201)英语(302)数学二(434)计算机原理中国协和医科大学(005)基础医学院(083100)生物医学工程(03)生物医学信号的检测与分析彭屹共1人(专业)1(101)政治(201)英语(302)数学二(434)计算机原

• DesignofPAP-1,aSelectiveSmallMoleculeKv1.3Blocker,fortheSuppressionofEffectorMemoryTCellsinAutoimmuneDiseases

  PharmaceuticalInstitute,UniversityofKiel,Kiel,Germany(A.Sc.,K.S.-L.,W.H.)DepartmentofMedicalPharmacologyandToxicology,UniversityofCalifornia,Davis,Davis,California(A.Sa.,P.A.,D.H.,H.W.)AbstractThelymp

• IdentificationofRegionsofthe-1ReceptorLigandBindingSiteUsingaNovelPhotoprobe

  auniqueclassofreceptorsthatcontainbindingsitesforawiderangeofligands,includingthedrug1-N(2‘,6‘-dimethylmorpholino)3-(4-t-butylpropylamine)(fenpropimorph),ayeaststerolisomeraseinhibitor.Becausefenpropi

• High-dosevitamintherapystimulatesvariantenzymeswithdecreasedcoenzymebindingaffinity(increasedKm):relevancetogeneticdiseaseandpolymorphisms

  Elson-SchwabandEliASilver1FromtheDepartmentofMolecularandCellularBiology,UniversityofCalifornia,Berkeley(BNA,IE-S,andEAS),andtheChildren‘sHospitalOaklandResearchInstitute,Oakland,CA(BNAandIE-S).2Suppo

• LiveCellAnalysisofGProteinβ5ComplexFormation,Function,andTargeting

  a;5subunitdiffersfromotherβsubunitsinhavingdivergentsequenceandsubcellularlocalizationpatterns.Althoughβ52modulateseffectors,β5associateswithR7familyregulatorsofGproteinsignaling(RGS)pr

• 《杨敬斋针灸全书》：[卷之上]周身经穴赋

  手太阴肺大指侧(少商、鱼际)兮(太渊)穴(经渠)兮(列缺、孔最)兮(尽泽、侠白)共(天府)为(云门)与(中府)相接手阳明兮大肠之经循(商阳二间三间)而行、历(合谷阳溪)之过(偏历温溜)之膑、(下廉上廉三里)而近、(曲池肘五里)之程()上于(巨骨天鼎)纡乎(扶突禾)唇连(迎香)鼻迫、(胃)乃足之阳明、(厉兑)趋乎(内庭)过(陷谷冲阳)之分见(解溪丰隆)之神(下巨虚)兮(条口)陈(上巨虚)兮(三里)

• VitaminD3DerivativeswithAdamantaneorLactoneRingSideChainsareCellType-SelectiveVitaminDReceptorModulators

  【关键词】VitaminThevitaminDreceptor(VDR)mediatesthebiologicalactionsof1,25-dihydroxyvitaminD3[1,25(OH)2D3],theactiveformofvitaminD,whichregulatescalciumhomeostasis,immunity,cellulardifferentiation,andothe

• 《解围元薮》：[卷三]风疠各方

  通经利窍汤十三三十帖，按日服之，风疠初服药起，须以此开经络。第一日大黄荆芥桔梗归尾黄芩(各一钱)羌活防风连翘(各一钱二分)防己白芷(各八分)牛膝(七分)甘草(五分)第二日大黄羌活防风桔梗(各一钱)白芷防己归尾独活荆芥牛膝(各八分)甘草(五分)第三四日羌活桔梗防风黄芩(各二钱)白芷荆芥防己独活牛膝归尾(各八分)甘草(五分)腹中有积作痛，加制大黄一钱，心痛、大肠不利，则用生大黄一钱。第五六七八日羌活独

• Cysteine2.59(89)intheSecondTransmembraneDomainofHumanCB2ReceptorIsAccessiblewithintheLigandBindingCrevice:EvidenceforPossibleCB2Deviatio

  lle,Kentucky(R.Z.,Z.-H.S.)DepartmentofChemistryandBiochemistry,UniversityofNorthCarolinaGreensboro,Greensboro,NorthCarolina(D.P.H.,J.B.-N.,P.H.R.)AbstractInthisstudy,thesensitivityoftheCB2receptortome

• MutationStudiesofSer7.39andSer2.60intheHumanCB1CannabinoidReceptor:EvidenceforaSerine-InducedBendinCB1TransmembraneHelix7

  ngspace,precludingCP55,940binding.TheCB1cannabinoidreceptorisamemberoftheG-proteincoupledreceptor(GPCR)family1A,whichincludestheCB2receptorandtheprototyperhodopsin(Howlettetal.,2002;Reggio,2005).Thehu

• VitaminEAnalogs,aNovelGroupof“Mitocans,“asAnticancerAgents:TheImportanceofBeingRedox-Silent

  efficientanticanceragentfortreatingallneoplasticdiseasehasyettodeliverauniversallysuitablecompound(s).Themajorityofestablishedanticancerdrugseitherarenonselectiveorlosetheirefficacybecauseoftheconsta

• NeutralizationofPlasminogenActivatorInhibitorI(PAI-1)bytheSyntheticAntagonistPAI-749viaaDualMechanismofAction

  【关键词】NeutralizationPAI-749isapotentandselectivesyntheticantagonistofplasminogenactivatorinhibitor1(PAI-1)thatpreservedtissue-typeplasminogenactivator(tPA)andurokinase-typeplasminogenactivator(uPA)act

• Clonallyexpandednovelmultipotentstemcellsfromhumanbonemarrowregeneratemyocardiumaftermyocardialinfarction

  rmlayers.Basedonsurfacemarkerexpression,theseclonallyexpandedhumanBM-derivedmultipotentstemcells(hBMSCs)donotappeartobelongtoanypreviouslydescribedBM-derivedstemcellpopulation.Intramyocardialtransplan

• 1,1-Bis(3‘-Indolyl)-1-(p-substitutedphenyl)methanesInhibitGrowth,InduceApoptosis,andDecreasetheAndrogenReceptorinLNCaPProstateCancerCellsthroug

  【关键词】1,1-Bis(3‘-indolyl)-1-(p-substitutedphenyl)1,1-Bis(3‘-indolyl)-1-(p-substitutedphenyl)methanes(C-DIMs)containingpara-trifluoromethyl,t-butyl,andphenylgroupsareanovelclassofperoxisomeproliferator-

• ActivationoftheAdenosineA1ReceptorInhibitsHIV-1Tat-InducedApoptosisbyReducingNuclearFactor-BActivationandInducibleNitric-OxideSynthase

  【关键词】ActivationHumanimmunodeficiencyvirusdementia(HIV-D)isanonfocalcentralnervoussystemmanifestationcharacterizedbycognitive,behavioral,andmotorabnormalities.ThepathophysiologyofneuronaldamageinHIV-D

• The1b-AdrenoceptorExistsasaHigher-OrderOligomer:EffectiveOligomerizationIsRequiredforReceptorMaturation,SurfaceDelivery,andFunction

  roteins,weestablishedconditionstomonitorsequentialthree-colorfluorescenceresonanceenergytransfer(3-FRET)andusedthesetodetectoligomericcomplexesofthe1b-adrenoceptorinsinglelivingcells.Mutationofputativ

• 17β-EstradiolPromotesBreastCancerCellProliferation-InducingStromalCell-DerivedFactor-1-MediatedEpidermalGrowthFactorReceptorTransactivation:Reve

  【关键词】17β-EstradiolThecoordinatedactivityofestrogensandepidermalgrowthfactorreceptor(EGFR)familyagonistsrepresentsthemaindeterminantofbreastcancercellproliferation.Stromalcell-derivedfactor-1(SDF-1)en

• 《解围元薮》：卷四

  参术遇仙丹百另二治三十六种大风诸恶危症。人参白术(各一两)川芎皂角刺本蝉壳天麻(各二两)羌活独活细辛紫参丹参沙参知母(各三两)元参当归荆芥穗红花苍术(各四两)穿山甲僵蚕蜈蚣漏芦萆石斛秦艽(各一两)乳香没药血竭(各七钱五分)麝香(五分)木香(二两五钱)地龙(八钱)苦参皮(半斤)上为末，蜜丸桐子大。每服五十丸温酒下，忌牛、羊、猪肉、野味、鸡、鹅、烧酒、房事，避风为上。子和方百另三五经风症少人知金肺伤风

• 《伤科方书》：通用方

  解肌汤广皮(一钱)。防风(一钱)葛根(一钱)。木通(一钱)。羌活(一钱二分)。荆芥(一钱五分)。前胡(一钱)。桔梗(一钱)。苏叶(一钱五分)。加葱白(三根)。姜(三片)。水煎服。小柴胡汤柴胡(一钱)。桔梗(八分)。连翘(一钱二分)。花粉(一钱五分)。葛根(一钱)。黄芩(一钱)。广皮(一钱)。木通(一钱五分)。加灯心(十根)。砂仁末(五分)。水煎服。十三味加减汤五加皮(一钱五分)。枳壳(一钱)。刘

• MolecularAspectsofAntitumorEffectsofaNewPlatinum(IV)Drug

  【关键词】MolecularAspectsThenewplatinum(IV)complexcis,trans,cis-[PtCl2(CH3COO)2-(NH3)(1-adamantylamine)][adamplatin(IV)]seemspromisingfortheperspectiveapplicationintherapyofcorrespondingtumors.Itistheref

• VasoactiveIntestinalPeptideTransactivatestheAndrogenReceptorthroughaProteinKinaseA-DependentExtracellularSignal-RegulatedKinasePathwayinProst

  soactiveintestinalpeptide(VIP),aneuropeptide,mayactasasurvivalfactorforprostatecancercellsunderandrogendeprivation.However,themolecularmechanismsbywhichVIPpromotestheandrogen-independentgrowthofandrog

• RegulationofLysophosphatidicAcidReceptorExpressionandFunctioninHumanSynoviocytes:ImplicationsforRheumatoidArthritis?

  【关键词】RegulationLysophosphatidicacid(LPA),viainteractionwithitsG-proteincoupledreceptors,isinvolvedinvariouspathologicalconditions.ExtracellularLPAismainlyproducedbytheenzymeautotaxin(ATX).Usingfibrob

• SeparatingTransrepressionandTransactivation:ADistressingDivorcefortheGlucocorticoidReceptor?

  【关键词】SeparatingGlucocorticoids(corticosteroids)arehighlyeffectiveincombatinginflammationinthecontextofavarietyofdiseases.However,clinicalutilitycanbecompromisedbythedevelopmentofsideeffects,manyofwhi

• EnvironmentalChemical-InducedBoneMarrowBCellApoptosis:DeathReceptor-IndependentActivationofaCaspase-3toCaspase-8Pathway

  DepartmentofEnvironmentalHealth,BostonUniversitySchoolofPublicHealth(H.-Y.R.,J.J.S.,D.H.S.)andDepartmentofMicrobiology,BostonUniversitySchoolofMedicine(J.K.E.,L.L.A.),Boston,MassachusettsEliLillyCo.,

• Synaptopodinregulatestheactin-bundlingactivityof-actinininanisoform-specificmanner

  isthefoundingmemberofanovelclassofproline-richactin-associatedproteinshighlyexpressedintelencephalicdendritesandrenalpodocytes.Synaptopodin-deficient(synpo–/–)micelackthedendriticspineapparatusanddisp

• DocosahexaenoicAcidInducesIncreasesin[Ca2+]iviaInositol1,4,5-TriphosphateProductionandActivatesProteinKinaseCand-viaPhosphatidylserineBindi

  tsofdocosahexaenoicacid(DHA;22:6n-3)oncalciumsignalinganddeterminedtheimplicationofphospholipaseC(PLC)andproteinkinaseC(PKC)inthispathway.DHAinduceddose-dependentincreasesin[Ca2+]i,whichwerecontribute

• Structure-FunctionStudiesofAllostericAgonismatM2MuscarinicAcetylcholineReceptors

  【关键词】Structure-FunctionTheM2muscarinicacetylcholinereceptor(mAChR)possessesatleastonebindingsiteforallostericmodulatorsthatisdependentontheresidues172EDGE175,Tyr177,andThr423.However,thecontributionof

• TransformingGrowthFactor-1ImpairsEndothelin-1-MediatedContractionofBrainVesselsbyInducingMitogen-ActivatedProtein(MAP)KinasePhosphatase-1andI

  【关键词】TransformingBrainlevelsoftransforminggrowthfactor-1(TGF-1)areincreasedinAlzheimer‘sdiseaseandhavebeenimplicatedintheassociatedcerebrovascularpathology.Werecentlyreportedthattransgenicmicethatove

• UntranslatedRegion-DependentExclusiveExpressionofHigh-SensitivitySubformsof42and32NicotinicAcetylcholineReceptors

  translated42nicotinicacetylcholinereceptors(nAChRs)arerecognizedastheprincipalnicotinebindingsiteinbrain.Recombinant42nAChRdemonstratebiphasicconcentration-responserelationshipswithlow-andhigh-EC50co

• Tyr702IsanImportantDeterminantofAgonistBindingandDomainClosureoftheLigand-BindingCoreofGluR2

  BiostructuralResearch,DepartmentofMedicinalChemistry(A.F.,B.V.,C.K.,B.B.N.,J.R.G.,M.G.,J.S.K.)andDepartmentofPharmacology(D.S.P.,A.S.),DanishUniversityofPharmaceuticalSciences,Copenhagen,DenmarkDipart

• RationalDevelopmentofHistoneDeacetylaseInhibitorsasAnticancerAgents:AReview

  d(M.R.A.,A.S.,W.D.F.)DepartmentofPharmaceutics,SchoolofPharmacy,VirginiaCommonwealthUniversity,Richmond,Virginia(M.R.A.,J.V.)AbstractTheepigenomeisdefinedbyDNAmethylationpatternsandtheassociatedpost-t

• InfiltrationofCOX-2–expressingmacrophagesisaprerequisiteforIL-1?–inducedneovascularizationandtumorgrowth

  L-1?–orVEGF-inducedangiogenesis.Theformerwasreducedinmonocytechemoattractantprotein-1–deficient(MCP-1–/–)micecomparedwithwild-typemice.Afterday4,clodronateliposomes,whichkillmacrophages,reducedIL-1?–i

• MolecularInteractionofaPotentNonpeptideAgonistwiththeChemokineReceptorCCR8

  MostnonpeptideantagonistsforCC-chemokinereceptorsshareacommonpharmacophorewithacentrallylocated,positivelychargedaminethatinteractswiththehighlyconservedglutamicacid(Glu)locatedinposition6oftransmembr

• 4-Hydroxy-2-nonenalAdductionofExtracellularSignal-RegulatedKinase(Erk)andtheInhibitionofHepatocyteErk-Est-LikeProtein-1-ActivatingProtein-1Sign

  【关键词】4-Hydroxy-2-nonenal4-Hydroxy-2-nonenal(4-HNE)isamajorlipidperoxidation(LPO)productformedduringoxidativestress.4-HNEishighlyreactivetowardcellularnucleophilesandisimplicatedintheevolutionofnumerou

• ModifiedReceptorInternalizationuponCoexpressionof5-HT1BReceptorand5-HT2BReceptors

  izationwereobserved.Antibodyknockdownexperimentsrevealedthatinternalizationof5-HT1Breceptors(expressedalone)wasentirelyclathrin-independentandCaveolin1-dependent,whereasthatof5-HT2Breceptors(expressed

• Lipoproteins,nutrition,andheartdisease

  ftheUSDepartmentofAgricultureortheNationalInstitutesofHealth.5SupportedbytheUSDepartmentofAgricultureResearchService(contract53-3K06-5-10)andtheNationalInstitutesofHealth(grantsHL39326andHL57477).6Ad

• MutationsLinkedtoAutosomalDominantNocturnalFrontalLobeEpilepsyAffectAllostericCa2+Activationofthe42NicotinicAcetylcholineReceptor

  fTechnology,Pasadena,California(N.O.R.-P.,H.A.L.,B.N.C.)Luxtera,Inc.,Carlsbad,California(T.J.P.)MolecularDevicesCorp.,UnionCity,California(A.F.)AbstractExtracellularCa2+robustlypotentiatestheacetylch

• X-linkedsusceptibilitytomycobacteriaiscausedbymutationsinNEMOimpairingCD40-dependentIL-12production

  eneticsofInfectiousDiseases,UniversityofParisReneDescartes-InstitutNationaldelaSanteetdelaRechercheMedicale(INSERM)U550,NeckerMedicalSchool;2LaboratoryofEnzymaticRegulationofCellularActivities,URA218

• Signalsforstresserythropoiesisareintegratedviaanerythropoietinreceptor–phosphotyrosine-343–Stat5axis

  amelioratedbyerythropoietin(Epo).Presentstudiesrevealthat,unlikesteady-stateerythropoiesis,erythropoiesisduringanemiadependssharplyonanEporeceptor–phosphotyrosine-343–Stat5signalingaxis.Inmiceexpress

• NKTcell–dependentleukemiaeradicationfollowingstemcellmobilizationwithpotentG-CSFanalogs

  shavepivotalrolesinimmuneregulationandtumorimmunosurveillance.WereportthattheG-CSFandFMS-liketyrosinekinase3ligand(Flt-3L)chimericcytokine,progenipoietin-1,markedlyexpandsthesplenicandhepaticNKTcellpo

• HumanADPKDprimarycystepithelialcellswithanovel,singlecodondeletioninthePKD1geneexhibitdefectiveciliarypolycystinlocalizationandlossoff

  【摘要】Autosomaldominantpolycystickidneydisease(ADPKD)geneproductspolycystin-1(PC1)andpolycystin-2(PC2)colocalizeintheapicalmonociliaofrenalepithelialcells.MouseandhumanrenalcellswithoutPC1proteinshowim

• Hypoxia-InducibleFactor-1(HIF-1)

  【关键词】HIF-1Adaptationtolowoxygentension(hypoxia)incellsandtissuesleadstothetranscriptionalinductionofaseriesofgenesthatparticipateinangiogenesis,ironmetabolism,glucosemetabolism,andcellproliferation/s

• ExpressionofCOX-2inplatelet-monocyteinteractionsoccursviacombinatorialregulationinvolvingadhesionandcytokinesignaling

  ,aproinflammatorycytokine,promotedstabilizationofCOX-2mRNAbysilencingoftheAU-richmRNAdecayelement(ARE)inthe3‘-untranslatedregion(3‘UTR)ofthemRNA.ConsistentwithobservedmRNAstabilization,activatedplate

• Receptor-MediatedActivationofHeterotrimericG-Proteins:CurrentStructuralInsights

  【关键词】G-protein-coupledG-protein-coupledreceptors(GPCRs)serveascatalyticactivatorsofheterotrimericG-proteins(Gβ)byexchangingGTPfortheboundGDPontheGsubunit.Thisguaninenucleotideexchangefactoractiv

• High-AffinityCationBindingtoOrganicCationTransporter1InducesMovementofHelix11andBlocksTransportafterMutationsinaModeledInteractionDomain

  【关键词】High-AffinityVoltage-clampfluorometrywasperformedwithacysteine-deprivedmutantofratorganiccationtransporter1(rOCT1)inwhichPhe483intransmembrane-helix(TMH)11closetotheextracellularsurfacewasreplace

• Tightjunctionbiologyandkidneydysfunction

  DivisionsofNephrology,1VeteransAffairsGreaterLosAngelesHealthcareSystem(VISN22),3UCLAMedicalCenterand4King/DrewMedicalCenterand2DavidGeffenSchoolofMedicine,UniversityofCalifornia,LosAngeles,Californi

• ThehematopoieticfactorG-CSFisaneuronalligandthatcounteractsprogrammedcelldeathanddrivesneurogenesis

  initiatedwithinashortwindowoftime,sothatonlyasmallpercentageofallstrokepatientsundergothrombolysis(1).Numerousneuroprotectivestrategiesaimingatimportantmechanismssuchasglutamatetoxicityorfreeradicalf

• ApolipoproteinEInterruptsInterleukin-1ßSignalinginVascularSmoothMuscleCells

  【摘要】Objectives-ApolipoproteinE(apoE)exertsantiatherogeniceffectsbutprecisemechanismsremainunclear.WehereinvestigatedtheeffectofapoEonintracellularsignalingbyinterleukin-1ß(IL-1ß),aproinfla

• SynergisticNeuroprotectionbyBis(7)-tacrineviaConcurrentBlockadeofN-Methyl-D-aspartateReceptorsandNeuronalNitric-OxideSynthase

  【关键词】SynergisticTheexcessiveactivationoftheN-methyl-D-aspartatereceptor(NMDAR)/nitricoxide(NO)pathwayhasbeenproposedtobeinvolvedintheneuropathologyofvariousneurodegenerativedisorders.Inthisstudy,NOwas

• PulmonaryDendriticCells

  ,Ghent,BelgiumABSTRACTDendriticcells(DCs)areleukocytesthatareemergingaschieforchestratorsofimmuneresponses.ThecrucialtaskofDCsisthecontinuoussurveillanceofantigen-exposedsitesthroughoutthebody,andthe

• Voltage-SensitiveOxonolDyesAreNovelLarge-ConductanceCa2+-ActivatedK+ChannelActivatorsSelectivefor1and4butNotfor2Subunits

  【关键词】Ca2+-activatedThelarge-conductanceCa2+-activatedK+(BK)channelisactivatedbyboththeincreaseofintracellularCa2+concentrationandmembranedepolarization.TheBKchannelplayscrucialrolesasakeymoleculeinthe

• >>点此搜索更多相关文献